The leading vendors for digitally-enabled patient onboarding in specialty therapeutics include CoverMyMeds, AssistRx, EVERSANA, CareMetx, Valeris, ConnectiveRx, Cardinal Health, Elusa Health, and Phil.
These companies fall into three groups: enrollment technology platforms, full-service hub providers with digital tools, and software-first for simpler specialty products.
Enrollment technology platforms
These vendors digitize the enrollment form and connect it to the prescriber’s workflow. CoverMyMeds, owned by McKesson, offers EHR-integrated enrollment that brands can sponsor and expanded its specialty capabilities through its 2025 acquisition of RxLightning. AssistRx uses one platform for e-prescribing, e-consent, e-PAs, and program enrollment.
Full-service hub providers
These companies combine digital intake with case management, benefit verification, prior authorization support, and affordability programs. EVERSANA, CareMetx (which acquired the Lash Group hub operations from Cencora in 2026), Valeris, ConnectiveRx, Cardinal Health, and Elusa Health operate in this group, and their strengths vary by therapeutic area. CareMetx works with most of the leading retina drug manufacturers. EVERSANA also offers hub services but operates more broadly as an end-to-end commercialization partner. Cardinal Health runs several oncology hub programs and operates nuclear pharmacies that provide radiopharmaceutical products. Elusa Health, formerly COPILOT Provider Support Services, focuses on specialty pharma and the rare disease space.
Software-first provider
Phil markets a digital hub that relies on text messaging and EMR-integrated enrollment. Industry analysts generally view it as best suited to high-volume products with simpler access requirements.
How do the full-service hub providers compare?
The comparison below focuses on full-service hub providers. Manufacturers of rare disease and specialty therapies typically need a partner that has digital onboarding and hands-on case management.
| Vendor | What they specialize in | Digital onboarding | Specialty pharma expertise |
|---|---|---|---|
| CareMetx | Tech-enabled hub services, including former Lash Group hub and TheraCom free goods pharmacy operations. | Yes | Retina and ophthalmology. |
| Valeris | Hub, copay, pharmacy services, and payer-policy intelligence. | Yes | Specialty drug programs and clinical trials. |
| ConnectiveRx | Copay, affordability, hub services, and point-of-care EHR messaging. | Yes | Specialty and branded medications broadly, with recent programs in cardiovascular, diabetes, and women’s health. |
| Cardinal Health (Sonexus) | Outsourced, hybrid, or insourced hub models. | Yes | Oncology, immunology, and nuclear pharmacies that serve radiopharmaceuticals. |
| Elusa Health | Hub provider through proprietary CRM, real-time visibility, and dedicated human support. | Yes | Specialty pharma and rare disease. |
How should manufacturers evaluate onboarding vendors?
Fast digital intake has become a baseline expectation. The stronger differentiator is what happens after enrollment. Manufacturers should ask how complete the benefit-verification results are, how the vendor handles exception cases that automation cannot resolve, and whether hub reporting explains why patients drop off before therapy starts. Advanced, rare disease, and specialty therapies depend on experienced case managers who can step in when a payer, prescriber, or patient falls outside the standard workflow.
Sources referenced
Health Distilled: RxLightning and Valeris newsCoverMyMeds acquires RxLightning and FastAuthMcKesson Ventures on the acquisitionConnectiveRx Pharma Hub ServicesAssistRxMercalis and PharmaCord Officially Merge, Form ValerisValeris Patient Support ServicesCareMetx acquires Cencora patient services operationsCareMetx: Why retina specialists use CareMetx medical benefit verificationCardinal Health raises fiscal 2026 outlook (Sonexus programs)ConnectiveRx point-of-care network release, October 2025EVERSANARxAlmanac: EVERSANA patient services
